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Although these general notions are widely accepted, a closer look shows that the functional state of TIL remains ill-defined and would deserve a more stringent examination.
As a more stringent examination, we performed the comparison to a background distribution that takes into consideration the proportion of sites inside and outside disordered regions (see Materials and Methods).
More stringent examination requires the use of chronic arthritis models such as CIA in Vβ 12 T-cell receptor transgenic mice [ 31] and use of therapeutic molecules that actually reverse established disease, for example IL-4 [ 32] and IL-1 inhibitors [ 22, 33].
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Looking at the issue more broadly, Arthur believes that more stringent examinations are necessary for new trainers, as well as a new and on-going system of education for existing trainers that places greater emphasis on general standards of horsemanship.
The objectives of this study were to provide preliminary evidence that this at-risk status for depression is associated with metabolic and inflammatory markers and to inform future, more stringent examinations of the directionality of these associations.
A more stringent test was with the 2D models.
A more stringent test of the model is needed.
A more stringent test is docking to unliganded structures.
Therefore, further examination of more stringent cut-offs are warranted, as are other approaches such as examination of interactions using the full sample in larger studies with both continuous and categorical outcomes.
A potential problem of clinical examinations is known as the hawk-dove problem, some examiners being more stringent and requiring a higher performance than other examiners who are more lenient.
Energy Secretary Bill Richardson's plan to require about 800 laboratory employees to undergo polygraph examinations as part of a more stringent counterintelligence program has drawn intense criticism from laboratory employees over the past few months.
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CEO of Professional Science Editing for Scientists @ prosciediting.com