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To build a more reliable network, the user can choose to use a smaller, more stringent database [ 33].
In cancer proteomics field, proteogenomics has been applied to identify SNVs that result in single amino acid variations SAVs), by constructing specialized database containing SAVs and developing more stringent database searching algorithm [ 4, 5].
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It should be noted that the hosts of the ChemSpider database developed more stringent acceptance criteria regarding vendor catalogues soon after the initial release of the database [28].
All of them are in cluster 1 and 5 (Table S1), indicating that the TargetScan database is more stringent with potentially lower sensitivity than miRBase.
Aside from increased numbers of mismatched concepts from the GO, the criteria used by curators for establishing that a GO annotation is fit for inclusion in the GOA database are more stringent than the criteria for establishing a gene-disease association.
This custom CDF reorganized probe sets based on i) more stringent gene/transcript definitions from UniGene database, and ii) alignment analyses performed on each single probe included in the probeset [ 30].
Once they are in the government's database, they face more stringent penalties if they are caught in the United States again.
Additionally, the sequence database applied is a comparatively small database which also requires a more stringent cutoff to exclude false positive hits.
Sequence databases have introduced more stringent requirements for submitters meaning that running an annotation pipeline alone is not enough to ensure acceptance of the genome annotation [ 9, 10].
Like many other pharmacovigilance data analyses, our proposed associations between ADEs and high-dimensional drug interactions need further molecular experimental validation, and using a more stringent pharmacoepidemiological study design and alternative databases.
In this present study, protein identification is more stringent and we used the probabilistic approach of decoy database searching [40].
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