The second and more stringent consideration derives from the demonstration that recipients of kidney allografts KSHV-negative prior to transplantation may develop KS lesions containing KSHV-infected neoplastic cells of donor origin.
Our goal is here to propose a more stringent no-arbitrage condition, which not only accounts for the nonlinearity of the market, but also explicitly refers to a family of contracts under consideration.
Recommendations suggest that the goals should be individualized, such that (1) certain populations (children, pregnant women, and elderly patients) require special considerations and (2) more stringent glycemic goals (i.e., a normal HbA1c < 6.0%) may further reduce complications at the cost of increased risk of hypoglycemia.
Given the nature of the study, these data are likely to reflect real world blood pressure management, and any consideration of retaining more stringent blood pressure targets (particularly if low values are proved to be unnecessary in those with pre-existing cardiovascular disease 8) has to consider the impact of at least aiming for lower blood pressure to achieve values ≤140/90 mm Hg.
For example, their more stringent segregation requirements and lack of consideration of functional experimental (e.g. patch-clamp) evidence likely led to their classification of three variants that we considered as "known pathogenic" as "variants of unknown significance", i.e., CACNA1S p.T1354S, SCN5A p.T220I, and SCN5A p.E428K.
These are much higher spending levels than mandated in Massachusetts, and more stringent than any of the plans currently under consideration in Congress.
So there is an alternative to depending, deliberatively, on finding a dimension in terms of which considerations can be ranked as "stronger" or "better" or "more stringent": one can instead "prune and adjust" with an eye to building more mutual support among the considerations that one endorses on due reflection.
Compared to the organism-wide zinc reduction through dietary uptake limitation, more stringent restriction of zinc in only pathologically affected regions is worth consideration.
Facing the possibility of more stringent laws, the Patients Federationn expressed concern that the prospective law under consideration was focused too narrowly on social protection, while ignoring patients' rights[ 83].
The differences in our study resulted from usage of the updated TAIR10.02 annotation and more stringent criteria; namely the exclusive combination of machine learning with sequence identity and consideration of the genomic context (e.g. synteny).
