Sentence examples for more stringent assay from inspiring English sources

In a more stringent assay, when treatment started after E. coli 5770 bacteraemia had already been established, three doses of 10 mg/kg A3-APO prolonged early survival at a rate similar to that of imipenem and reduced the bacterial counts to base level.

While the mice do not exhibit deficits on the accelerating rotarod, they do show deficits on the balance beam, a more stringent assay to detect gait disorders in mice.

The MDA-MB-435Br1 MDA-MB-435Br1 MDA-MB-435Br1erimental brain metastases following injecelln into the intra-carotid artery, yet it shows significantlineowereadilyty to metastasize in the more stringent assay oformsntanexperimentalsis [ 12].

As we need to develop at least some measure of pathogenicity of anti-dsDNA antibodies, we propose that initial anti-dsDNA antibody screening is done by sensitive ELISA and supplemented by more stringent assays.

ELISA screening (for lower avidity anti-dsDNA antibodies) followed by risk stratification through the use of more stringent assays (Farr, EliA, Crithidia) and restricting the relevance of anti-dsDNA antibody presence to specific clinical manifestations might provide us with a better index of the pathogenicity of anti-dsDNA antibodies.

Consequently we chose GRFN-1 as our lead compound and re-tested a broader range of concentrations in the TZM-bl assay as well as in the more stringent p24gag antigen release assay using immortalized CD4+ lymphoblastic PM1 cells (Figure 4B).

We chose TFs as they are typically expressed at lower levels than non-TF-coding genes and are therefore in general more difficult to detect (24, 25), thus rendering this validation assay more stringent than when a number of genes is targeted coding for a diverse set of proteins.

Thus, the tsBN67 rescue assay is more stringent than the HeLa-cell G1-to-S progression assay because single-copy Domain 1 and 2 constructs are relatively less active in the tsBN67 rescue assay than the HeLa-cell G1-to-S phase progression assay.

To further assess the influence of C2GnT1 expression on E-selectin binding of LS174T cells, we performed more stringent hydrodynamic shear flow assays that closely simulate forces occurring in the microvasculature.

Thus, in theory and in practice, split YFP assays integrate cellular conditions and are more stringent than yeast two-hybrid assays.

We find, however, that the Basic region requirements for promoting cell proliferation in a temperature-sensitive tsBN67 cell assay are more stringent than for G1-to-S phase progression in an HCF-1 siRNA-depletion HeLa-cell assay.