However, there are constraints on distance and orientation from the protein backbone, which are more stringent for activity toward substrates than for autophosphorylation.
Because Boolean criteria do not allow such variability in the subcriteria scores as does DAS28, at any timepoint fewer patients fulfil Boolean remission due to the originally more stringent disease activity criteria.
Separating leisure time physical activity "elsewhere" from that "at home" led to a more stringent measure of physical activity during leisure, as confirmed by its clear association with HRV.
In the case of cell encapsulation, a variety of cytocompatible photopolymerization conditions have been identified that proceed at physiological temperature and osmolarity, but conditions for encapsulation of proteins while maintaining activity are more stringent.
Being by nature nonshiftable, these activities are more stringent for caregivers with employment.
In most cases, the corporate culture needs to be changed in that it promotes health management with even more stringent measures when neglecting certain activities".
Although originally defined by a disease activity score in 28 joints (DAS28) <2.6, more stringent criteria may imply the absence of disease activity.
We chose the −77/+57 NXNL1 fragment as the scaffold for these experiments because this minimal promoter sequence contains needed core RNA polymerase II binding elements, since it is active in Y79 and HEK 293 cells (Figure 2A), but it is by itself insufficient for transcriptional activity in the more stringent and biologically relevant environment of retinal explants (Figures 3A and 4).
American College of Rheumatology (ACR -European LeACR -EuropeanRheumatism (EULeagueecommendAgainst[ 2] advocate using moRheumatismnt rEULARion crecommendations the Simplified Disease Activity Index (SDAI) and a Boolean definition.
Even at a much more stringent confidence level applied to the high activity data (p ≤ 1e-7), 22 of the 25 genes bound at low activity are still found, plus an additional 137 bound genes.
