Perhaps the late-2004 additiof of Alliance Bernstein, a more strict value shop, as co-managers has improved results.
To adjust for multiple testing we considered a more strict P-value (<0.005) as statistically significant.
Prophage Finder was first tested with default parameters and second with a more strict E value threshold (1e-3).
To generate an objective comparison, we defined a relatively loose criterion based on nominal P-values, i.e., the tier one criterion (nominal P-value < 0.01), and a more strict criterion based on adjusted P-values after multiple testing correction, i.e., the tier two criterion (FDR < 0.2).
However, more strict blood pressure control (attaining values <120 mmHg for systolic blood pressure together with RAS suppression and of course other medications) could be partly deleterious for renal function as shown by the ACCORD (Action to Control Cardiovascular Risk in Diabetes) study (8).
After adjustment for false detection rate or the more strict Bonferroni correction (multiply each P-value by the number of microRNAs tested, ∼1000), most P-values remain highly significant (Table 2 lists unadjusted P-values; P-values are mostly below 1e-8).
A small value will detect more signals, but more potential noise will go through; a high value will be more strict but potentially will not let actual source signals through.
"If, for example, a genomics study were to identify a susceptible population at risk due to exposure to a contaminant at a Superfund site through a correlation of genomic analysis of local populations and measured or expected exposure levels, the Agency might choose to reduce the RfD/RfC [inhalation reference concentration/oral reference dose] value and propose more strict remediation measures.
To identify the most important and specific differences, we subsequently chose a more strict selection criteria (FC > 5 and p-value < 0.001).
To overcome this discrepancy, the review suggested that lipid reference values in black children should be more strict, in order to achieve a prevalence of the metabolic syndrome which would correspond better with actual cardiometabolic outcome.
