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A dataset was constructed in two steps, first an initial selection of potential sequences and later a more strict selection based on a Hobohm1 [35] homology reduction algorithm.
The more strict selection of prey motion and shape also makes it more difficult to feed mandarin fish with artificial diets and dead prey fish.
To identify the most important and specific differences, we subsequently chose a more strict selection criteria (FC > 5 and p-value < 0.001).
In particular, we over-sampled people from the area close to the river (area 4), which was expected to be the most contaminated, and women, which had more strict selection criteria.
Since large sets of DEG were found more strict selection cutoffs have been used: adjusted p value < 0.01 (by both packages) and absolute log 2 fold-changes > 1. See Supplemental Table 1 in Supplementary Material available online at http://dx.doi.org/10.1155/2015/731938 for complete test results.
However, we applied a targeted approach, and if we had used a more strict selection of putative SNPs this would, in our case, decreased the total number of putative SNPs rather than led to selection of other putative SNPs in the target genes that were more likely to pass the genotype validation.
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A first approach could be to allow less persons to participate by applying more strict 'selection at the gates'.
This underlines the evolutionary importance of these genes, as the lack of paralogs most likely means that they are under more strict control and selection than most other genes.
In an open-label study, this level was achieved in about 15 min in more than 90% of events treated by IV-MO, despite selection criteria were more strict and included episodes with a high intensity (more of 7/10 on a numerical scale) (Mercadante et al, 2004).
Patients entering into clinical trials are required to fit into selection criteria that are generally far more strict than those that are used to select patients for routine treatments.
Such control may have emerged through the selection of specific mutations enabling more strict control of PFK1 activities by one of its downstream products, the TCA cycle intermediate citric acid.
More suggestions(15)
more efficient selection
more accurate selection
more conservative selection
more refined selection
more open selection
more strict constraint
more rounded selection
more positive selection
more daring selection
more careful selection
more diverse selection
more exotic selection
more natural selection
more strict exclusion
more strict definition
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