Non-coding RNA HOTAIR or its more stable DNAme surrogate may indicate the presence of a subset of cells which confer resistance to carboplatin and can serve as (1) a marker to personalise treatment and (2) a novel target to overcome carboplatin resistance.
This aldehyde surrogate is more stable and liberates the corresponding aldehyde 31 in situ under the basic conditions of the transaminase reaction, resulting in an 84%% yield of (R -lactam 32.
Since MR-proADM and ADM are stoichiometrically generated and MR-proADM is more stable [28], MR-proADM seems to be at least a reliable surrogate marker for the active hormone ADM.
This concept is appealing, because (i) a DNA-based biomarker is more stable and (ii) would provide a spatially and temporally more comprehensive surrogate for cancer biology compared with a snap-shot RNA assessment.
Instead, copeptin, the more stable C-terminal fragment of provasopressin, has emerged as a promising surrogate for vasopressin in the characterization of the role of the arginine vasopressin system in CVD.
We believe that DNA methylation markers could be more informative, as they are more stable than other candidate biomarkers such as RNA or protein-based markers, and can act as a surrogate for environmental exposures (20).
Which isomer is more stable?
