Sentence examples for more stable secondary from inspiring English sources

It was found that the use of the AMBER polarisable force field ff02 in combination with the polarisable POL3 water potential results in a more stable secondary structure of this complex and a more consistent predicted free energy of binding with different simulation approaches (single-trajectory, multiple short-trajectory and independent-trajectory simulations).

However, a more stable secondary structure (−50 kcal/mol) in the same position presents an impenetrable barrier to 40S ribosome scanning [30], [33].

Surprisingly, our analysis showed that abundant PK transcripts carry longer 5'UTRs with higher GC-content that form more stable secondary structures, as compared to rare PK transcripts.

In line with previous studies [37], the HPS haplotype codes for a longer more stable secondary structure in the val158 region relative to the APS haplotype.

Furthermore, the greater decrease in translation of TU-1B in comparison with TU-1A might be explained by a higher composition of G/C nucleotides within the 5'UTR sequence of the former, its overall more stable secondary structure, and its longer 5'UTR sequence.

This small but statistically significant bias of eIF4E upregulated sequences towards a more stable secondary structure near the end of the 5'UTR region is consistent with a model of ribosomal scanning and unwinding of secondary structure with the eIF4A helicase [8], [37].

Increased GC content in 5'UTRs of abundant transcripts allows formation of more stable RNA secondary structures that may serve as scaffolds for RNA-binding proteins, promote a more compact folding and increased mRNA stability.

The HPS haplotype, however, exhibits a marked 20-fold reduction in enzymatic activity paralleled by reduced protein translation efficiency due to formation of a longer more stable mRNA secondary structure with a 17 kcal/mol reduction in Gibbs free energy [37].

Generally, the lower the MFE, the more stable the secondary structure of a given RNA sequences.

Alternative splice sites tend to be GC-enriched and exhibit more stable RNA secondary structures in all of the considered species.

For example, trans-acting responsive element (TAR) and Rev-responsive element (RRE), both of which are recognized by the Tat protein and Rev protein respectively, have more stable local secondary structures than other regions of HIV-1 genome [ 23- 25].