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More stable peptides may then further tip the balance in favor of L. lactis.
The modifications introduced into Antp-LP4 and N-Ter-Antp included using a shorter sequence, and/or D-amino acids, leading to effective and more stable peptides.
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On the contrary, for pAntp peptide the increase of P/L ratio after membrane saturation results in a very low decrease of aggregation suggesting a more stable peptide-lipid interaction.
They find that larger particles lead to formation of more stable peptide MHC complexes on DCs leading to prolonged antigen presentation and longer DC/T-cell contact durations which leads to the enhanced formation of Tfh cells.
However the two cyclization strategies employed have different effects, with disulfide cyclization resulting in more active peptides while backbone cyclization results in more proteolytically stable peptides.
We also demonstrate that β-peptide helicity governs antifungal activity, with more stable β-peptides possessing antifungal activity at lower concentrations than less stable molecules at the same hydrophobicity.
This resulted in the design of analog peptides 33208 and 33210 displaying an α-helix more stable than peptide 11438 as predicted by using AGADIR and molecular dynamic analysis and determined by CD analysis.
After identifying the active site of AFP as an eight-amino acid peptide (Mesfin et al, 2000), Mesfin went on to develop a more stable, cyclised peptide with substantial potential as a pharmaceutical agent (Mesfin et al, 2001).
With the recent availability of an immunoassay that measures the more stable ADH precursor peptide (CT-ProVasopressin), we sought to investigate whether increased ADH levels would explain hyponatremia found in Legionella patients.
Yet, with the recent availability of an immuno-assay measuring the more stable ADH precursor-peptide (CT-ProVasopressin) that is produced in equimolar ratio to ADH, this problem can now be addressed [ 33].
These non-peptide inhibitors can be more stable than inhibitors containing peptide bonds, because they will not be substrates for peptidases and are less likely to be degraded.
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