Sentence examples for more stable hypoxia from inspiring English sources
The CoCl2 method has the advantage of being fast and inexpensive and provides a more stable hypoxia that is not possible with hypoxic chambers (Wu and Yotnda 2011).
The relaxant effects of GW0742 10 300 µM) or vehicle (DMSO; 0.4%) were examined during the second, and more stable, exposure to hypoxia.
The mimic reductive activation study revealed that compound 15c exerted reductive activation properties under hypoxia, which were consistent with the in vitro metabolic study, wherein 15c was easily reductive activated under hypoxia and much more stable under normoxia.
We chose the vhl mutant line as a model for hypoxia as we believed that genetic inactivation of vhl offered a stronger and more stable activation of the Hif pathway than pharmacological activation or physical hypoxia, whilst avoiding complications due to developmental retardation and other abnormalities resulting secondarily from severe hypoxia.
Genes within Group 3 are more highly expressed in subtype B, and are enriched for elements involved in interactions with the extracellular matrix, collagen production, focal adhesion, hypoxia, glycolysis, immune response, and protein export, suggesting that this group may represent a more stable vasculature.
Considering the more stable nature of miRNAs compared to the more labile mRNAs, miR-210-3p may show a better potential as intrinsic hypoxia marker for GBM tumor samples than VEGF and CA9 (7,8).
The choice of an ideal hypoxia marker would favour probes that have low lipophilicity and resistance to hypoxia-independent degradation; in general 2-nitroimidazoles with an amide side chain typified by etanidazole are more stable to nonhypoxic metabolism than those with a hydroxypropyl side chain such as misonidazole (Aboagye et al, 1998).
Which isomer is more stable?
