Sentence examples for more stable derivatives from inspiring English sources
In addition, HA can be easily modified to obtain more stable derivatives that are more resistant to enzymatic or hydrolytic degradation.
Because of the surprisingly low hydrolysis stability of these cycloSal PMEA derivatives, more stable derivatives were designed.
6 In contrast, bifunctional neutral dichlorido RuII agents containing tethered ligands of general formula [(η:η-arene:N RuCl2], Figure 1, as well as the more stable derivatives [(η:η-arene:N Ru(oxalate)], 7, 8 have proved to be inactive.
Perhaps surprisingly, the authors only observed a modest increase in circulating PGE2 (and PGD2) levels in FAP patients, but the levels of TXA2 (inferred by measurement of its more stable derivative TXB2) were dramatically elevated in both FAP and sporadic colorectal cancer patients relative to healthy individuals.
A considerable effort in the HDI field has led to the development of more stable TSA derivatives such as Vorinistat ® (SAHA), which was recently approved for limited applications like treatment of CTCL [33], [34], [35], [36].
Simple DTPA derivatives are generally preferred here, although luminescence development methods have also been established that enable the exploitation of the more stable DOTA derivatives.
Other authors have supposed that adhesions could be reduced with more stable HA derivatives and HA could be fixed to the tendon surface, and its removal could be minimized [ 8– 19, 19, 20].
The more stable dinaphthyl derivative (t1/2 = 125 min) (Entry 4, Table 3) was retained in pulmonary capillaries due to its high lipophilicity (cLog P = 6.47).
Therefore, efforts have been undertaken to generate more stable Cl-amidine derivatives that resist proteolysis in vivo.
Consequently, it appears that S-alkylation of compound 1 leads to a more stable dithiocarbamate ester derivative that resulted in lower anticancer activity in the prostate cancer cell lines.
Darko et al. have developed even more stable conformationally strained TCO derivatives (d-TCO) and studied their stability and reaction kinetics [51].
