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Spontaneous conversion from the native form of serpins into a more stable conformation, called the "latent" form, is restricted.
This transition state provides the macromolecular network more freedom of chain motion, which allows it to rearrange to a more stable conformation.
Clearly, the simulations conducted in this study demonstrate that abacavir affords an increased stabilization from peptide P3 resulting in a more stable conformation and lower DS (and eM) than acyclovir.
The increase in the thin film's birefringence may be attributed to the thermodynamic driving force for crystallization causing the plane of the phenyl group to orient more perpendicular to the plane of the substrate, evidently the more stable conformation for poly chloro-p-xylylene).
This technique, normally performed in aqueous solution, induces the protein and its ligand to adopt a more stable conformation, closer to in vivo state [16], [17].
Comparison of the conformational changes in the trimethyl and the dimethyl groups showed that the trimethyl groups continuously rotate, whereas the dimethyl group keeps its more stable conformation.
Similar(37)
Such reversible switching between two or more stable conformations mimics the intracellular movement of protein biomotors.
The single V67L mutation significantly slows hydrogen-exchange rates globally, indicating a shift to more stable conformations and reduction in ensemble distribution.
During four 50-ns molecular dynamic simulations in aqueous solution, the DNA nanostructures adsorbed onto graphene demonstrated more stable conformations with lower root mean square deviations and smaller coordinate changes in the z-axis direction than the DNA nanostructures that were not adsorbed onto graphene.
The structural changes in LPKCL protein caused expansion of the protein structure, as suggested by the increased ROG of more stable conformations.
It is interesting to note that both principles, switching through dynamic states or between more stable conformations have also been discussed for HAMP domains (Ferris et al., 2011, 2012; Zhu et al., 2013; Ames et al., 2014; Mechaly et al., 2014; Stewart, 2014), consistent with the idea that the output domain may mirror the behavior of the regulatory domains.
More suggestions(15)
more twisted conformation
more active conformation
more symmetric conformation
more stable society
more stable way
more stable exchange
more inactive conformation
more stable community
more stable system
more functional conformation
more stable world
more stable land
more stable footing
more authentic conformation
more coily conformation
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