Sentence examples for more stable activation from inspiring English sources

We chose the vhl mutant line as a model for hypoxia as we believed that genetic inactivation of vhl offered a stronger and more stable activation of the Hif pathway than pharmacological activation or physical hypoxia, whilst avoiding complications due to developmental retardation and other abnormalities resulting secondarily from severe hypoxia.

The mutant C408V provided a more stable enzyme for activation of CPT-11.

These results are in agreement with the kinetic thermodynamic connection: a thermodynamically more stable C H bond activation product results from the lowest energy transition state.

The RC frame showed highly pinched behavior, whereas the hysteresis curves of strengthened frames were more stable due to the activation of FD and/or MD, forming a larger loop area.

Since type I viral glycoproteins are converted from a metastable native state to a much more stable state after fusion activation [36], we postulate that the increased acid requirement exhibited by the mutant EnvB proteins may be due to their increased stability relative to the wild-type glycoprotein.

Activation of TP by TxA2, or by more stable synthetic agonists, evokes the activation of phospholipase C and a subsequent rise in the intracellular calcium ion concentration, leading to vasoconstriction and platelet aggregation [ 72, 73].

The 15.7 kcal/mol energy difference between the transition states TS2 M1andnd TS8 M1a results from the formation of a four-membered palladacycle in the case of C2 H activation versus a more stable five-membered palladacycle in the C8 H activation.

However, DNA methylation was the key modification that accompanied the formation of an inaccessible chromatin structure and more stable gene silencing upon cellular activation and through cell division.

Since the common Treg signature was considerably more stable after in vivo Treg activation by DC, our experimental system may recapitulate the behavior of Treg in a natural immune response more accurately.

In vitro studies have demonstrated that Fos/Jun heterodimers are more stable and efficient in driving transcriptional activation than a Jun/Jun homodimer [ 14]. c-Jun is frequently overexpressed in human cancers.

In conclusion, the regulation of SOD3 expression in carcinogenesis involves ras oncogene-driven sequential events consisting of both reversible mechanisms that correlate with the RAS activation levels and more stable epigenetic events.