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The sample H4 containing 10 mg/ml of HPMC and 10 mg/ml of vancomycin had more spherical structure and lowest particle size distribution.
First, it has been shown that among proteins of the same size, α/β proteins have, on average, a greater number of contacts per residue due to their more compact (i.e., more "spherical") structure [32], [33].
We suggest the following explanation: the slower folding for multi-state proteins of the same size can be explained by their more spherical structure so the expected surface of the boundary between folded and unfolded phases in the transition state [16] for a more spherical protein is larger than that for a non-spherical protein (see Figure 5).
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In both cases, the structures rapidly relaxed into more spherical structures, in agreement with a liquid-like state.
How then do serpins fold to the aspherical final structure while avoiding more stable and more spherical structures such as the latent state?
To explore more spherical YS structures, the rough shells were formed with large surface area.
In summary, the packing of the BR1 and BR2 exon sequences takes place in distinct and reproducible steps; a 7-nm fibre is folded into an irregular 19-nm fibre and subsequently folded into a more compact, eventually spherical structure.
We hypothesized that the shape is more complex than originally believed, and cannot be accurately modeled as a spherical structure.
The nanolaminas also served as new nucleation sites for more nanolaminas growth and the eventual development into a well-defined three-dimensional spherical structure.
The loading capacity of yolk @ cage-shell hollow spherical ACP is twice more than that of ACP-24-2 and ACP-48-2, which indicates that yolk @ cage-shell hollowhicherindicatescthat contributed to the drug's loading.
The HRTEM tests indicate that hollow spherical structure and Zr compound coating layer can dramatically suppress Mn dissolution in electrolyte and make the crystal structure more stable during the electrode process.
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