To be more specific, "signal feature is positive and significant" means that the mean signal of a feature is greater than the corresponding background and that this difference is significant.
These assays were based on the fluorogenic oligoprobe chemistry, which uses the 5´-exonuclease activity of the DNA polymerase to generate a more specific signal than that produced by the use of SYBR Green I (8).
Antibodies to either the GFP- or the FLAG- tag were able to detect the fusion protein in col-99::egfp::flag worm lysates, but the anti-FLAG monoclonal antibody showed a more specific signal (Additional file 3).
Antibody-conjugated quantum dots have demonstrated brighter and more specific signals as well as superior photostability compared to traditional organic FITC dyes.
With refinement of signal transduction components, stronger and more specific signaling pathways may be possible.
Moreover, the CD133+CXCR4+CD34- cells derived from the DMD blood cultured in the presence of endothelial medium give rise to a higher number of endothelial colonies than those from the normal counterpart, indicating that these cells probably receive more specific signals for endothelial differentiation from DMD tissues.
While the interaction of specialists with their host plants may involve additional more specific signals and more restricted signaling pathways, this can also result in a down-regulation of host defenses.
The second GO module covered signal transduction (GO 0007165) and more specific signaling pathway relevant terms, which corresponds to a significant sub gene set with the signal transduction function [21].
They do not seem to have a pleiotropic effect on cellular regulation like the transceptor's signaling to the PKA pathway, but rather control more specific signaling pathways that regulate the expression of regular glucose or amino acid transporters, respectively.
While potentially providing more specific signals than microarray, bead-based flow cytometric miRNA profiling methods require the removal of genomic DNA, followed by recovery of small RNA fragments [ 17]; these multiple steps have the potential to alter the miRNAs present in the original sample.
Either way, we imagine that altered Cdk5 activity must produce another, more-specific, signal, perhaps one related to the MB axonal swellings, that cooperates with accelerated aging to produce frank, tissue-level degeneration.
