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In the WMI, rarer domains receive higher weights assuming that rarer domains are associated to more specific pathways.
This indicates that ENO1-mRNA has no general toxicity to cells but seems to work through one or more specific pathways.
More specific pathways are also well represented, such as androgen and estrogen metabolism or steroid biosynthesis, as illustrated in Additional file 4, Figure S4.
Gene expression analyses were performed at this sub-category level and for more specific pathways within each of these sub-categories (Additional file 1: Table S1).
Results showed the P-values more significant by an approximately one order of magnitude indicating that more specific pathways lead to more informative analyses.
Evolutionarily conserved Rabs are usually expressed in all cell and tissue types and regulate more fundamental vesicle transport pathways whereas the less conserved Rab family members function in more specific pathways, which are often organ-dependent.
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A more specific pathway to ABA biosynthesis starts from the epoxidation of zeaxanthin and antheraxanthin to violaxanthin, which occurs in chloroplasts and other plastids and is catalyzed by a zeaxanthin epoxidase (ZEP) (Agrawal et al., 2001).
They do not seem to have a pleiotropic effect on cellular regulation like the transceptor's signaling to the PKA pathway, but rather control more specific signaling pathways that regulate the expression of regular glucose or amino acid transporters, respectively.
Excluding seven broad pathways, between 1 20 metabolites fell into 73 more specific KEGG pathways (Additional file 4).
Overall, 43 % of the lncRNAs with co-expressed protein coding genes showed enrichment for at least one or more specific functional pathways (Additional file 8) such as CD40 upregulation and CD40 downregulation pathways (Fig. 4c).
Therefore, Breivik and Glaudernack's hypothesis for distinct carcinogens to exert their effect on two proposed types of genetic instability, i.e., microsatellite instability and chromosomal instability [ 16], may be extended to the potential effect of carcinogens on more specific genetic pathways to colorectal tumorigenesis, as for example the KRAS mutated pathway.
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more specific possibilities
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