If you feel that all of the content is necessary to your point, but the paragraph is still too long, you should think about breaking it up into several smaller, more specific paragraphs.
It might be best to start from the more general and move to the more specific in each paragraph.
INPP4B, PTPLA and COMMD6 showed, in addition to splicing differences between blood cells and solid tissues, a switch in alternative splicing during blood differentiation (Figure 4) and are therefore described in more detail in a specific paragraph.
The topic sentence should act as a middle ground in your paragraph: it should be slightly more specific than your thesis, but it should not encompass the information from your entire paragraph.
A topic sentence should act as a transitional gateway to its paragraph: it should be slightly more specific than your thesis, but it should not summarize all of the information from the paragraph.
For both the GGP and SHARE, no biological data are collected, contrary to the more specific longitudinal surveys discussed in the previous paragraphs.
Your body paragraph (or paragraphs) should provide additional context and information and more specific details about your request.
For this reason, we first describe how we expect performance to change with treatments, and then, in the next paragraph, describe the specific performance metrics used, and more specific predictions of how we expected them to change.
Also, in the same paragraph, the authors compare miRNAs to protein inhibitors, which are described as more specific and/or selective.
I would also like to ask whether the Secretariat could be more specific on the results of the Netherlands' evaluation of the FAO Special Relief Operation, which is referred to in paragraph 34.
