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The ABCC4 model may be used as a working tool for experimental studies on ABCC4 and design of more specific membrane transport modulating agents (MTMA).
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Each Rab protein regulates one (or more) specific step of intracellular membrane traffic in eukaryotic cells, probably by assembling the general tethering/docking/fusion machinery [ 96].
These range from a general placement, such as in the "cell membrane" to more specific, such as the "histone deacteylase complex".
In addition to these universal functions, the plasma membrane has a more specific role in multicellular organisms.
This effect can be quantitatively accounted for by a two-stage process in which weak association of HA with the membrane surface precedes more specific and tighter binding to the glycan receptor.
HAMLET was distributed in patches on PMV membranes, indicating that specific membrane regions bound HAMLET more strongly than others.
Nuclear membrane targeting by SUN2 may be more specific than that achieved with WPP because the former involves a transmembrane domain whereas the latter is likely to associate more loosely with the membrane through electrostatic interactions.
Offering only a limited potential for diversification, this example highlights the possibility that more specific roles are associated with these repeat domains in some types of membrane proteins.
Hence, the binding facility of W-tagged peptides seem to include not only lipid membranes and LPS, as demonstrated in the present investigations, but also more specific targets.
Alternatively, membrane targeting in metazoans may represent the first targeting step that precedes a more specific docking event.
More specific.
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