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In some other studies, more specific derivatives of the Western pattern have been characterised such as the 'junk food', the 'red meat', the 'high fat/high sugar' or the 'sweets and salty snacks' pattern.
Given the number of targets affected by curcumin and its poor bioavailability, efforts have been directed at improving its chemical properties by complexing it with lipids/phospholipids [ 55, 56] and developing more specific derivatives [ 35, 57- 59].
Interference with proteasome activity, although initially considered unlikely to be exploitable clinically, has already proved to be very effective against haematological malignancies, and more specific derivatives that target subsets of proteasomes are emerging.
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As a first approach to verify this and to determine if it would be possible to design a more specific derivative, we have built a homology model of the E. cuniculi aminopeptidase.
These antigens are more specific than those in the purified protein derivative (PPD) because they do not cross-react with BCG or M. avium complex [ 8].
A more specific behavior is observed for the nitrobenzene sulfonate derivative.
IGRAs are in-vitro blood tests based on interferon-γ release after T-cell stimulation by antigens more specific to Mycobacterium tuberculosis (Mtb) than the purified protein derivative used in TST.
The RD1 sequence is missing from M. bovis Bacille Calmette-Guerin (BCG), and this omission makes these antigens more specific for M. tuberculosis infection diagnosis than the purified protein derivative (PPD) [ 1- 3].
This conclusion is based on the stronger HSC depletion when Cxcl12 was deleted using the Prx1-Cre line which targets somatic lateral plate mesoderm and its derivatives, including chondrogenic and osteogenic lineages compared to deletion in more specific stromal populations.
Also, many of the categories selected by the tensor models were more specific than those we found previously (e.g., protein metabolism vs. amino acid and derivative metabolism).
Given the promising results of the application of fasudil and Y-27632 and its derivatives in the clinic, great efforts have been invested in the discovery of other more powerful and more specific ROCK inhibitors.
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