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Characterization of these and the more specific compounds will help validating these targets in leukemia and other oncological diseases.
Thus, more general compounds can only serve as sinks of more specific compounds in the Yeast 5 GEM, and not as sources.
An understanding of the molecular mechanisms that are triggered by a substance possibly may widen its field of indication or promote the development of more specific compounds.
Further studies with more specific compounds are needed to separate the Cl− current dependent on NO as shown by Matchkov et al. [ 17] and Boedtkjer et al. [ 18] from the Ca2+-dependent Cl− current in vascular smooth muscle cells.
TSPO ligands, including benzodiazepines and more specific compounds represented by the diagnostic ligand PK11195, have been shown to attenuate cancer cell proliferation, to have neuroprotective effects, and to inhibit the MPTP.
Better results are expected by the design of more specific compounds, acting on specific populations of cannabinoid receptors, as suggested by discoveries of specific neuroprotective population of cannabinoid receptors [ 56].
Similar(53)
In comparison, the more specific compound PP2 that only inhibits the Src family of tyrosine kinases caused a much stronger reduction in cell number, in particular at the 10 μmol/l concentration.
Since this work does not include the isolation of bioactive compounds from the Moringa Oleifera leaf extract, we are not able to propose one or more specific active compounds to be mediating the cellular anti-cancer effects demonstrated in our results.
In particular, understanding the nutritional preferences for complex oligosaccharides for members of the microbiota will help in the future in the selection of specific desirable probiotic strains, as well as a change towards more specific prebiotic compounds.
Nevertheless, the specificity and/or bioavailability of SB431542 may be suboptimal for in vivo studies, and there certainly exists the potential for more specific inhibitor compounds to produce improved results.
It is thus likely that DMNT is a more specific suppressive compound than both linalool isomers, and that the suppressive mechanism is highly sensitive to very low concentrations of DMNT.
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more specific components
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more estrogenic compounds
more specific questions
more predictive compounds
more specific moves
more specific exceptions
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more hydrophobic compounds
more phenolic compounds
more populated compounds
more specific differences
more oxygenated compounds
more complex compounds
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more similar compounds
more volatile compounds
more active compounds
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