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Second, it will be useful to examine the effectiveness of this signature in more specific breast cancer subtypes, for example in ER+ LN+ (LN-positive) and ER+ LN-.
Because no significant difference in FOXA1 and GATA3 mRNA expression was observed in the ER-positive group, we decided to explore a more specific breast cancer subtype.
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New assays directed at the biological processes specific to breast cancer conducted using test methods relevant to breast tissue might well prove to be more specific to breast cancer than were those whose results are currently available through literature review.
Although BCS contains several emotion-related items, those items are more specific to breast cancer patients than those in the EWB subscales, e.g., " I feel sexually attractive," " I am able to feel like a woman", etc.
One hope is that we can build upon our previous success with targeted endocrine and ErbB2-targeted therapy to develop a more effective treatment that is more specifically designed for specific breast cancer types.
Newer radiopharmaceuticals targeted to particular aspects of breast cancer biology will likely play an important role in directing more specific and individualized breast cancer treatment.
While anatomic techniques continue to evolve with improvements in spatial resolution and image quality (examples include computer-aided detection and digital mammography as well as other anatomic imaging methods such as MRI and ultrasound), molecular imaging may provide a more specific targeting of breast cancer tissue and greater contrast between tumor and normal tissue.
Together with the development of more specific radionuclide tracers for breast cancer, this may further improve the detection rate of PET/CT [22].
As lesion size upon discovery decreases with more efficient screening programs, the need for a non-invasive tool that provides more specific information on small breast lesions becomes obvious.
Briefly, FACT-B is a 44-item self-report questionnaire designed to measure general quality of life issues as well as more specific issues related to breast cancer, and it has been extensively used in both research and clinical practice.
Cheang reported that the expanded surrogate of PgR, HER2, EGFR, and cytokeratin 5/6 indicate a more specific definition of basal-like breast cancer, mostly TNBC, which better predicts breast cancer survival [ 5].
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