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Hierarchical analysis of enriched categories from the parent GO terms (levels 1 2) down to categories describing more specific biologic processes (levels 3 9) revealed a number of functions and pathways relevant to the biology of airway basal cells.
These therapies confer major long-term toxicities in over 90% of long-term survivors; therefore, efforts are underway to identify more specific biologic therapies with less toxicity and better efficacy at targeting NB.
The business of performing clinical trials is complex - and perhaps never more so than when a potent mix of immunosuppressive drugs is supplemented with a far more specific biologic, in the hope of getting better disease control in patients with hard-to-treat autoimmune conditions.
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Examination of a single trait shared by cases of a disorder (e.g., impaired social cognition in ASD) reduces outcome heterogeneity and may allow for identification of a more specific exposure-related biologic pathway.
However, when reliability and statistical power considerations dictate the need for collecting more specific exposure information, more extensive environmental, biologic, and personal exposure measurements should be obtained from various "validation" subsets of the NCS population that include children who are in different life stages.
The increasing use of biologics has allowed a more specific and targeted approach to the treatment of various hematological malignancies and other autoimmune disorders in which B-cell or humoral mechanisms appear to play a role in disease pathogenesis.
The advent of biologic agents has provided a more specific and targeted approach to the treatment of various hematological malignancies and other autoimmune disorders.
Second, we must establish larger collaborative trials, which are more efficient, have larger cohorts and quicker pipelines, and address specific biologic aims.
Specific biologic aberrations in medulloblastoma will become increasingly more important therapeutically as an attempt is made to decrease the high morbidity associated with current medulloblastoma treatment strategies.
There are a number of possible ways to screen chemicals for prioritizing for future testing, including quantitative structure activity relationship predictions, high-throughput screening for a specific biologic activity, or in vitro assays that mimic one or more critical biologic events that occur as part of the reproductive process.
Finally, knowledge of CTCL genetics could improve biologic understanding of this group of diseases and facilitate the development of more specific, targeted therapies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com