Sentence examples for more sophisticated sequence from inspiring English sources

Additional assessments of siRNA specificity reveal that more sophisticated sequence comparison tools are also required to minimize potential off-target effects (Jackson et al., 2003; Semizarov et al., 2003).

Second, the emergence of more sophisticated sequence searching algorithms, such as profile-profile matching [2], improve the probability of finding a suitable search model, even in cases of very low similarity (<20% identity).

Over the last decade or more, much more sophisticated sequence comparison techniques have been developed that can confirm homology even in the midnight zone of sequence similarity (<20% sequence identity).

More sophisticated sequence-based methods of measuring antigenic distances for influenza viruses have been explored by He and Deem in a series of papers involving, for example, identification of clusters of 2009 H1N1 strains, connected according to time-ordered single amino acid mutations and minimal nucleotide mutations [ 38].

The development of more sophisticated sequencing technologies in the early 21st century led to the discovery of more fusion genes in solid tumors.

With the development of more sophisticated sequencing technologies came the discovery of fusion genes in solid tumors, including sarcoma, carcinoma, and tumors of the central nervous system.

Although many FAD mutations in APP and PSEN1 have been well-characterized over the past 20 years, the advent of more sophisticated sequencing techniques allows for the identification of an infinite number of genetic changes associated with AD which could not only give insight into disease pathogenesis but also identify novel therapeutic candidates.

In this perspective, SAW could be further improved by a more sophisticated consensus sequence generation method, or by generating more than one consensus sequence per short read cluster.

However, it can give a decisive indication that will count strongly towards attributing the more sophisticated number sequence construction.

The great interest for these important regulatory regions is leading to the development of more sophisticated RNA sequencing library preparation protocols (the more powerful will be the possibility to entirely sequence the untranslated region, the more accurate will the reconstruction of putative novel 3'UTRs be).

Using more sophisticated genetic-sequencing techniques, scientists recently looked to see how many species of crustaceans alone they could find.