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A more sophisticated problem outlined by Hodgson (1967: 38) and others is that a promising convention is broadly speaking incompatible with an act utilitarian society.
As the referees have pointed out correctly, it is one thing to show that Hop1 is a conditional regulator of Red1 deposition (this can be derived from the ChIP-seq data with high certainty), but a more sophisticated problem to compare two ChIP-seq profiles and scale them correctly, relative to each other.
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The technique can be extended to more sophisticated problems with variable and distributed time delays.
These results demonstrate that the combination of the Wigner Monte Carlo method and Kohn Sham systems provides a reliable computational tool which could, eventually, be applied to more sophisticated problems.
Financial advisors say the range of miscues run from the very basic like not starting or not adequately funding one of these tax-deferred plans to more sophisticated problems like tolerating higher-than-necessary fees or poorly allocating a portfolio.
Admittedly, there's a mounting frustration as each level becomes increasingly complex, demanding faster and more sophisticated problem-solving skills.
The method is illustrated for a small size matrix from an affine matrix problem and is then applied to large matrices actually arising from more sophisticated control problems used in the design of the Boeing 767 jet and a nuclear powered turbo-generator.
During the 1980s Newell began work (unfinished) on applying this concept to another, more sophisticated, general problem-solving program that he named Soar.
When the system runs in a lower pressure, more efforts must be made to solve more sophisticated technical problems.
Some more sophisticated or problem-specific modifications can be introduced to the definition of CSD in Eq. 2.
And beyond the voyeurism aspect, Rad sees Passport as more of a sophisticated problem for Tinder users who travel frequently.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com