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Compared to DharmaFECT, PEI-NH-SWNTs gave rise to more significant suppression of GAPDH gene expression at a PEI-NH-SWNT/siGAPDH mass ratio of 1 1.
A more significant suppression of tumor angiogenesis was observed when Bev was used in combination with SNO-HSA (Fig. 5a).
Furthermore, in in vivo studies, systemic administration of doxorubicin followed by intratumoral injection of oncolytic HSV1 resulted in much more significant suppression of tumor growth with increased median survival period compared with each treatment given alone (p<0.05).
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As presented in Figure 4A, the combination therapy caused an even more significant tumor suppression (92%, p < 0.01), which has significant difference when compared to the therapy with sDll4 or sEphB4-Alb alone (p < 0.05).
On the tenth day, cell proliferation started to decrease and this decrease in cell proliferation was more significant in both the suppression group and the control group than in the experimental groups (P < 0.001), whereas the cell proliferation in the suppression group and the control group was not of a statistically significant difference (P > 0.001).
Guillen et al also found that children with complete viral suppression had more significant increases in height and weight when compared to children with inadequate viral suppression [ 27].
On the other hand, CT at more than 0.15 μM caused significant suppression of OPN production induced by TNF- α stimulation).
As shown in Figure 7, treatment of epithelial cells with LCT at more than 0.05 μM caused significant suppression of OPN mRNA expression, which was increased by TNF- α stimulation.
As shown in Figure 4(a), treatment of cells with CT at more than 0.1 μM caused significant suppression of GM-CSF production, which was increased by the stimulation of OPN.
As shown in Figure 9, treatment of cells with LCT at more than 0.05 μM caused significant suppression of NF- κB activation, which was increased by TNF- α stimulation.
On the other hand, in UV-induced epidermal proliferation, SAG Tg expression promotes the degradation of both c-Jun (pro-proliferation) and p27 (antiproliferation) with a net outcome of enhanced proliferation, suggesting a more significant role of p27 in suppression of UVB-induced skin proliferation.
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