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It was an embarrassment for such an accomplished rider but Dettori has endured more significant setbacks in recent years and has now reached the summit of Flat racing once again.
While aides to Mr. Green and Mr. Hevesi welcomed the support yesterday, the endorsements are probably more significant as setbacks to the relatively young campaigns of Mr. Ferrer and Mr. Vallone.
But rent control supporters also have suffered some setbacks, none more significant than the failure earlier this month of a California ballot initiative.
In a significant setback for a more unified Europe, Swedes voted overwhelmingly today to reject membership in the European single currency after a passionate referendum campaign, made uncertain to the last moment by the assassination of Foreign Minister Anna Lindh.
Later, President Obama's agreeing to a military surge of 30,000 more troops to Afghanistan, in Mr. Ramslien's view, was a significant setback to the process.
In a significant setback for Mrs May, diplomatic sources dismissed the speech as "more of the having your cake and eating it philosophy" and warned that it would not form a basis for talks.
"This is a significant setback.
This did feel like significant setback.
Is this a significant setback for Bitcoin?
It would also be a significant setback for Isis.
Losing the deal would be a significant setback for EMI.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com