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Relatively, promotion of glucose uptake seems to be the more significant function of FRF than, elicitation of insulin release.
Ryanodine-sensitive Ca2+ stores are present in photoreceptors and have been proposed to help maintain Ca2+ levels within a physiological range optimal for normal function under dim lights, whereas store-operated calcium entry and transient receptor potential channels might have a more significant function under bright and prolonged illumination.
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In their analysis authors also indicate cell-to-cell signalling and interaction as being the more significant functions of the differentially expressed genes.
Because of the variations between indica and japonica (Nipponbare reference genome), alignment procedure was set at lenient parameters to allow more significant mapping using the 'score function'.
For Kant had attributed the apriori the far more philosophically significant function of constituting the object of experience or knowledge.
Data from the functional assay indicated a more significant effect on function as only 5 of the Ala substitutions were functional (T181A, W183A, L184A, T186A and I187A), and each of these displayed a significant increase in the EC50 when compared to wild-type responses.
This result is consistent with the idea that the members of the core response module might be more significant to the functioning of the system, as indicated by their regulation in response to many different stimuli.
Expression of this variant in Xenopus oocytes showed alterations in activation and deactivations kinetics, but the changes were relatively mild compared with the previously reported KCNC3Phe448Leu mutation that displayed a much more significant gain-of-function in our heterologous expression system [6].
It is a particularly disabling disorder which is associated with greater comorbidity, more significant impairments in functioning, increased health care utilization, and more frequent suicide attempts and hospitalizations than acute major depressive episodes [ 1].
Differentiability is a much more significant property for complex functions than for real functions.
Furthermore, all subjects studied had a good level of renal function (serum creatinine ~1 mg/dl), and so it remains unclear how uTWEAK may be affected by more significant declines in renal function.
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