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In some ways, however, a more significant flaw opens up in the film's last hour, when the story is no longer about the Civil War's effects on the South, or about Scarlett's steel-willed striving to regain her fortune.
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However, each of these loci also possesses one or more significant flaws that make it less suitable either due to low PCR amplification success, low levels of sequence divergence, limited utility in non-angiosperms, and/or absence in some land plant lineages.
The Lions have a very talented roster with one flaw more significant than any other – the quarterback.
"Science Fictions" has one significant flaw.
More significant.
Regrettably, the Senate bill contains a significant flaw.
The lack of redress is a significant flaw.
The spokesman, Jim Branham, said: "It seems to us to be a pretty significant flaw".
"In my view, that represents a very significant flaw" in baseball's testing program, he said.
There are more significant challenges.
Hurricane Sandy also exposed a significant flaw in the initial design of the emergency system.
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CEO of Professional Science Editing for Scientists @ prosciediting.com