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For others, evacuations, power loss, falling trees, and flooding caused a much more significant disruption, leaving Zone A residents hoping for the appearance of an ark.
CD analysis revealed that l- or d-Pro incorporation into KLW reduces the α-helicity of the peptide and d-Pro incorporation induces more significant disruption in α-helical structure than l-Pro incorporation.
Male mice showed similar reductions in K5K8DP TECs but more severe reductions in cTEC and mTECs and a more significant disruption of cTEC morphology.
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Looming over it all is a likely cyclical downturn and potentially much more significant structural disruption to the global automotive industry, and the specter of a broader global recession, which could throw the ambitious plans of these companies to transform into broader-based mobility providers in doubt.
And his willingness to defy miserly central banker traditions and make large amounts of credit available after the 1987 stock market crash and again after the 1998 Asian economic crisis may well have averted far more significant economic disruptions.
Power outages have become more commonplace, resulting in significant disruption to business continuity and loss of economic value.
What does the rail industry say? Rail Delivery Group (RDG) chief executive Paul Plummer admitted that no one wanted to pay more to travel, "especially those who experienced significant disruption earlier this year".
It is possible that this will apply more so for conditions perceived as 'non-threatening' but causing significant disruption to everyday life.
More than 60 schools in Staffordshire have been closed and heavy snowfall caused significant disruption in the Moorlands area.
On Wednesday 30 November they could face more of the same when UK Border Agency staff go on strike, a move that could cause "significant disruption" at Britain's airports and ports.
Overall, genetic disruption of TPH2 resulted in a mild antidepressant phenotype, and this became much more significant in the DKO mice.
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