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PY1 has a more significant role in nuclear import than PY2, since mutation of PY1 results in a more significant defect than mutation of PY2.
Reductions in red cell counts, hematocrit and hemoglobin concentrations suggested a more significant defect in hematopoiesis and beyond the scid mutation (Qing et al., 2012).
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Struts normal to the build direction show more significant defects but their redundancy means that they do not compromise the compressive performance in the build direction.
We observed that glc7-E101Q cells had a more significant growth defect in limited glucose (2% glycerol, 0.08% glucose; YPAG) relative to its growth in rich medium (2% glucose; YPAD).
STAT5b-deficient mice have a more significant proliferation defect that cannot be corrected by high-dose IL-2, and decreased numbers of NK cells with diminished cytolytic activity [ 38].
In our series, knees that failed by medial tibial collapse had more significant bone defects and required more complex reconstructions than is currently reported in the literature.
More significant corneal defects have also been filled and reconstructed with multi-layered amniotic membrane [ 33].
Significant CAD was defined as the presence of one or more significant myocardial perfusion defects on MPI or one or more significant major epicardial coronary artery stenoses on CAG.
Based on these additional examinations, 70 high-risk patients without any cardiovascular symptoms was exposed to have significant CAD, defined as the presence of one or more significant myocardial perfusion defects on MPI, and/or one or more significant major epicardial coronary artery stenosis at CAG, and 63 of the high-risk patients had no significant CAD.
As for the effects of vacancy defects on the thermal conductance, we can see that for all diameters of SiNWs and all temperature regions, the pristine wire has the highest thermal conductance, and the vacancy effects are more significant for a center defect than for a surface defect.
This means that the width of the defect has more significant effects on the mechanical properties of KSiNWs than the length of the defect.
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