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Results: Inhibition of lymphotoxin α1β2/lymphotoxin-β receptor interactions was associated with increased severity of Citrobacter rodentium induced colitis, as indicated by increased disease-related mortality, more severe weight loss, intestinal bacterial abscesses, and a higher burden of Citrobacter rodentium in the spleen and liver of −/− and lymphotoxin-β receptor-immunoglobulin G-treated mice.
immunized animals were protected with little weight loss, but A/NP+M2-rAd i.m. immunized animals suffered more severe weight loss than at 1 month and 37.5% succumbed to infection (Figure 4D and E).
Additionally, mice deficient in mast cells due to their carriage of the Kitwsh/wsh mutation showed more severe weight loss and higher-grade pneumonia compared to WT mice infected with M. pulmonis.
Gasoline and diesel fuel can be supplemented with the use of battery power in terrestrial vehicles, however this is not a feasible option for aircraft, which have much more severe weight and size limitations.
Of note, free testosterone levels were below normal in one-third of HIV-infected women with normal weight, half of those with up to 10% of body weight loss, and two-thirds of those with more severe weight loss, of whom 38% were amenorrheic (Grinspoon et al, 1997).
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It is possible that in our study, more severe weight-for-height Z-scores might have been associated with a positive TST in the setting of active TB disease.
Depression is common among obesity sufferers and grows in prevalence the more severe the weight gain, says Lucy Faulconbridge, director of research at the University of Pennsylvania's Weight Loss and Eating Disorder clinic.
The increased inflammation found at this time point (day 14) in TLR2−/− mice also correlated with the more severe body weight loss and increased mortality during the first course of DSS in our long term study (Fig 1B C).
Perforin-2 heterozygous littermates had more severe initial weight loss than wild-type animals, but these animals were able to recover.
Interestingly, we observed that a subgroup of the TGF β1 transgenic mice showed more severe muscle weight loss while the rest exhibited milder pathology.
Gluten-sensitized mice treated with indomethacin exhibited a more severe retardation of weight gain after 7 weeks, compared to all groups (Figure S1).
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