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Classification based on acidity is useful because, while both acids and alkalis are corrosive to the eyes, skin, and intestinal tract, alkalis generally penetrate the tissue more deeply than acids and tend to cause more severe tissue damage.
PACAP deficient mice reacted with more severe tissue damage than wild types [97, 98].
Here, we found that, at admission, non-survivors patients at day-28 had more severe tissue hypoperfusion than non-survivors.
Pathologic examination revealed that the IL-18 treated mice had more severe tissue infiltration and inflammation of the lung, liver and gastrointestinal tracts (Supplemental Fig. S1 and S2).
Since an exaggerated inflammatory response could lead to more severe tissue damage, this enhanced inflammation could explain why TLR4−/− mice showed less tubular injury and a more preserved renal function compared with wild type mice upon I/R injury.
Lactate levels were significantly higher in nonsurvivor group indicating more severe tissue hypoperfusion compared to the survivor group of patients.
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Opioids, like morphine or OxyContin, are used for more severe tissue-type pain.
In addition, acute anemic conditions which produce mild brain tissue hypoxia have been associated with evidence of more severe renal tissue hypoxia [21, 28]; providing a plausible explanation for both stroke acute kidney injury (AKI) in patient exposed to hemodilutional anemia [12, 16].
Open fractures are also more frequently associated with higher energy trauma and more severe soft tissue injury.
With renal I/R injury, necrotic cell death results in further activation of inflammatory cascades, resulting in more severe secondary tissue damage [ 27].
Zheng and colleagues [ 5] detected glomerular microthrombi in 20% of LN patients, which was associated with poorer renal function as well as more severe renal tissue injury.
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