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Even without knowing the directionality of the changes, we can conclude that there is a dissociation between structural thalamo cortical brain changes in juvenile myoclonic epilepsy, along with aberrant functional thalamo cortical interactions that get worse as a function of disease severity as generalized tonic clonic seizures relate to more severe task-related dysfunction (Fig. 3A).

Wales' current players will, by now, be reflecting on the more severe tasks before them.

But almost all of them said that the problem was more severe before the task force existed.

However, the present findings could be hardly explained by a deficit in ToM since, if this was the case, one would expect to find a more severe difficulty with tasks in which self-other attribution is explicitly required, as on the Source Memory task.

Results: Stroke patients with ICH had significantly more severe deficits on a task of thinking operations than did patients with infarction.

It is not unreasonable to speculate that these costs might be more severe under increasingly complex, realistic task conditions (e.g., when driving) (Strayer et al., 2003).

Personalising bias for negative events was associated with poorer IQ, a tendency to make perseverative errors, a poorer performance on the second order false belief task and more severe symptoms.

Increased BOLD activation after TBI has been positively correlated with both more severe injury and better fMRI task performance (Newsome et al. 2007; Scheibel et al. 2007, 2009), lending some support to its role as an injury-specific compensatory mechanism.

Interestingly, this increase in activation had a linear dose relationship to injury severity, with stronger activation with more severe TBI, when adjusted for age, education, and fMRI task performance.

An external observer may have rated these individuals as having more severe problems with carrying out the tasks than the participants self-assessment, however the contextual information that they have provided suggests that their judgments reflects adaptations they have made in their daily lives.

Hence, assuming a correlation between tic severity and inhibitory deficits one could speculate that patients with more severe tics might show performance deficits in inhibitory tasks.

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