In about 10 percent of people with discoid lupus, the disease will evolve into the more severe systemic form of the disorder.
In both animal models and patients, direct injury to the lung is characterized by more severe lung epithelial damage, and an indirect insult to the lung is characterized by more severe systemic endothelial injury [24 26].
Combining the CPG groups also showed a higher probability of a more severe systemic event in comparison to the non-CPG group (OR 9.14, 95% CI 1.01, 83.04, p = 0.0493).
Furthermore, Bt2 causes more severe systemic disease than Bt1, including conjunctivitis, ruffled skin, tibiotarsal arthritis, reduced spontaneous activity, and neonatal mortality [7], [8], [9], [10], [12], [13], [14], [15], [16], [17].
Surprisingly, NK1.1 depleted mice did not appear to have much more severe systemic morbidity as their weight loss did not exceed 10% of initial weight, in contrast with isotype treated mice, which lost significantly more weight during the peak of infection (Figure 5F).
It may, however, predispose the individual to a more severe systemic reaction.
Therefore, more severe passive systemic anaphylaxis in SRC-3-/ mice is due to increased cytokine production in mast cells.
Our results suggest that the more severe the systemic reaction to the insult, the higher and the more prolonged the CRP levels.
However, in about 15% of cases, the clinical outcome is more severe and systemic complications can ultimately lead to death [ 6].
However, if fever reflects more severe or systemic disease, this finding contradicts previous reports suggesting influenza A(H3) was associated with such illness [ 16, 41].
In more severe cases systemic retinoids [ 15, 16] or corticosteroids [ 14, 15] have been used, as has oral vitamin A (retinol) [ 14].
