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Similarly, analysis of symptom subtypes in the Baltimore Epidemiologic Catchment Area study found more severe subtypes were associated with female gender and family history but not stressful life events, while mild or moderate cases were associated with family history and stressful events, but not female gender [ 23].
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Based on the features described above, we thus conclude that HCV-positive TG is likely to be a more severe subtype of TG.
These findings further support the idea that depression which includes painful physical symptoms is a more severe subtype of depression [ 21].
This damage would add to other pathological processes that eventually manifest as rheumatoid factor antibodies in the common, more severe subtype of RA that is easier to diagnose.
Lebowitz et al. [ 9] clarify that chronic tic disorders (CTD) with coexisting obsessive compulsive disorder is a more severe subtype of CTD, characterized not only by more severe tics but also by e.g. poorer global functioning.
To our knowledge, this is the first time that an autoantigen is described that primarily drives autoreactive T-cell responses in the more severe subtype of JIA, namely polyarticular JIA, and this autoreactivity is persistent throughout the disease course.
The more severe JIA subtypes have a poor prognosis, with lack of response to intense immunosuppression in some cases.
Genetic studies of a rare, and more severe migraine subtype, Familial Hemiplegic Migraine (FHM), have identified mutations in three causal genes that code for ion channels involved in neuronal signalling and have provided hypotheses applicable to common migraine [8].
Indeed, previous studies have suggested that shoplifting behavior may define a more severe eating disorder subtype [ 10, 12, 22- 25].
Although RSV subtype A typically causes more severe disease than RSV subtype B (18 ), the PCR-based test used in our institution does not allow for RSV subtyping.
Disease due to influenza A/H3N2 viral subtype is significantly more severe than that due to influenza A/H1N1 subtype and influenza B virus, which indicates that the characteristics of the different viral types and subtypes should be adequately considered by health authorities when planning preventive and therapeutic measures.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com