Although this meta-analysis indicates only low heterogeneity, diversity between studies, for example due to different populations (e.g., countries, age groups), inclusion and exclusion criteria (e.g., more severe patients), study designs (e.g., inadequate follow-up of lost patients), statistical methods used, and various sources of bias, is still an important issue.
Parental psychopathology may be more severe in studies finding such confounding.
Pain scores at baseline were approximately 15 mm less than in our study, suggesting that pain was slightly more severe in our study.
For example, if the sample of study participants includes only those with more severe disease, the study will overestimate the sensitivity of the test since the test is more likely to be positive for these patients.
After switching medication, four response subgroups were detected: two with substantial treatment effects, both of which had more severe symptoms at study start, and two with little or no treatment effects, one of which had low initial symptom scores and one that had more severe symptoms at study start.
Polish DM patients seem to be more severe cases; our study reported almost twice as many hospitalisations per 100,000 inhabitants than in Sweden and hospital costs in Poland are more than 50%% lower (Table 7).
The reason might be the degree of chondral injuries in our model was more severe than previous studies, which presented fibrillation or chondromalacia as mild osteoarthritis induced gradually.
Perhaps a more severe limitation to studies of the SHR rat model of ADHD lies in the instability in the behavioral characteristics of its normotensive control rat, the WKY [ 44].
The toxicities were slightly more severe in the present study than in the ACCORD11 study, which presumably is attributed to the more frequent laboratory tests in the present study in Japan.
15, 20, 30, 31 In children, there was a male predominance at 1.4 1 in two studies, with one citing boys as having more severe involvement; a third study reported girls as having more severe disease.
