While rs2651899 (Prs1016694210166942 (TRPM8), and rs11172113 (LRP1) appear most important for common migraine (i.e., at the population level) [62], rs1835740 may play the major role in more severe forms of migraine (i.e., clinic-based populations) [57].
In contrast, mice deficient in TTP and TNFR-2 show a more severe phenotype, suggesting a protective role for this receptor [ 27].
Considering the cell culture and animal model data for VZV-MSP and the lost B-cell epitope resulting from the D150N gE mutation, this mutation should be monitored to determine whether it plays a role in more severe cases of varicella or zoster or in breakthrough varicella in previously immunized children.
We hypothesize that these multiple roles cause more severe replicative stress-associated phenotypes, which is supported by the stronger phenotype of the xpa-1 brc-1 double mutant.
In addition, the instillation of MCP-1-neutralizing antibodies into mouse lungs blocks cytokine secretion and induces more severe pneumonia, indicating a critical functional role of this particular chemokine.
The latter was also associated with a more severe radiographic grade, displaying its predictive role as OA marker progression.
All results from the clinical, serological and pathological data indicated that TLR3 ligand administration to the PIA rats could make the disease more severe, and further highlighted the important role of TLR3 in PIA development.
To reduce this risk, much information needs to be known about the biology of L. longipalpis sand flies, such as minimum temperature tolerance, mechanisms of urban spread, presence in aircraft, and role in inducing more severe disease.
Nevertheless, the more severe pathology certainly supports a direct role for DPPIV in inactivating pro-inflammatory substrates such as SDF-1α, particularly as the mouse form lacks ADA binding activity.
RP105-deficient mice developed more severe collagen-induced arthritisTo examine the role of RP105 in the development of CIA, RP105+/+ and RP105-/ littermate mice were immunized with CII and monitored for signs of arthritis.
