Although there is definitive data on pARB being more pathogenic or causing more severe illness than their antimicrobial-susceptible equivalents (Barza 2002; Helms et al. 2004, 2005; Travers and Barza 2002), that may not always be the case (Evans et al. 2009; Wassenaar et al. 2007).
The disease in North America can be attributed to two separate introduction events: the early epidemic caused by the non-aggressive sub-group O. ulmi and the later, more severe epidemic, caused by the highly pathogenic aggressive sub-group of O. novo-ulmi, which continues to threaten elm populations of Western Canada.
However, although this adaptive response is unable to completely prevent, it should still protect certain levels of pathogenic damage induced by diabetes; otherwise these pathogenic changes would be more severe and appear earlier.
An increase in BAFF and BAFF receptor was observed in EAMG tPA−/− mice, whereas BCMA expression was reduced, consistent with the increased level of pathogenic antibodies and the more severe disease.
However, the possible pathogenic mechanism for the more severe effect on enamel seen in patient 2 remains unclear.
Certainly, a putative virulence gene in a pathogenic organism might be more severe than the same gene in an otherwise harmless bacterium.
In autosomal dominant DC, the age of onset is earlier and the disease is more severe in later generations who carry the pathogenic mutation, a phenomenon known as anticipation (Vulliamy et al., 2001; Mason, 2003).
The statement of viral co-infections in acute bronchiolitis raised the question of a cumulative pathogenic effect and consequently a more severe disease, although other hypotheses as successive infections or healthy carriage might be also supported [23].
First, the increase in Aβ42 aggregation proneness associated with the pathogenic Arctic mutation (E22G) correlated with more severe detrimental effects on memory, locomotor ability, and lifespan than those caused by Aβ42 (Figure 2).
Both mouse models were more susceptible to caerulein-induced pancreatitis developing more severe pancreatitis underscoring the importance PRSS1 mutations as a pathogenic mediator [ 130, 131].
