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However, it remained under discussion that RSV is a more severe pathogen than HMPV, but systematic studies on this assumption were missing.
One of the hallmarks of the emergence of M. ulcerans as a more severe pathogen is the acquisition of a 174-kb plasmid that bears a cluster of genes necessary for the synthesis of the polyketide toxin mycolactone.
Indeed, we found that at H70, the drop in the living amoeba count with B. massiliensis was 85% although, with the more severe pathogen L. drancourtii, there was no living amoeba left at the same time post-infection.
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Many enteric viruses, bacterial pathogens, and parasites probably contribute to disease both individually and in combination [ 9], and together, co-infecting pathogens may cause more severe diarrhea than infections with each pathogen alone [ 10].
Rac-deficiency was associated with diminished TLR4 expression, impaired host clearance of the pathogen and more severe chronic arthritis.
The most common cause of RTI is viral, which may facilitate the conversion of asymptomatic carriage of SPn to a pathogen and pneumococcal disease may be more severe than that caused by other pathogens.
In these patients, UTI are more severe, caused by more resistant pathogens, and is associated with worse outcomes than in patients without diabetes.
Patients with at least one risk factor for MDR pathogens had more severe pneumonia on admission and a higher prevalence of severe sepsis compared with those without (45% versus 29%, P <0.001; 31% versus 21%, P = 0.001).
Patients co-infected with 2 tick-borne pathogens usually show more severe clinical signs of longer duration (1 ).
Targeting enzymes or metabolic pathways of bacterial origin in human pathogens should have more severe consequences for the parasite than for its host, making these proteins promising targets for chemotherapy.
Bacterial diarrhea and infection with more than one pathogen might produce a more severe illness.
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