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The commonest conditions predisposing patients to either acquiring infection or experiencing a more severe outcome are listed in Table 1, categorised with the mnemonic RENUC [1].
The risk factors are phenotyped according to the ORENUC system: O indicates no known risk factors; R, risk of recurrent UTIs but without risk of a more severe outcome; E, extraurogenital risk factors; N, relevant nephropathic diseases; U, urologic resolvable (transient) risk factors; C, permanent external urinary catheter and unresolved urologic risk factors.
The chronic and fatal inflammatory diseases are known to have a more severe outcome with advancing age [11].
While generally mild for most patients, the pandemic influenza A(H1N1) 2009 virus cause disproportionately more severe outcome in pregnant women.
Consequently, pneumonia could plausibly lead to a more severe outcome (i.e., death).
Resistant isolates have been associated with a more severe outcome of disease than that caused by non-resistant strains [ 28].
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Extending the recall period to AOM episodes occurring during the last 12-month period may have decreased accuracy in reporting, and a systematic bias could have been generated if only the more severe outcomes were reported or if the recollection of the severity of a given AOM episode is modified as time passes.
Assessment of VE with regards to disease severity showed there to be a higher association with protection against more severe outcomes (e.g., for those hospitalized).
More severe outcomes include dehydration, loss of fluids and electrolytes, and kidney and heart damage.
Background: Parvovirus B19 (PVB19) is an erythrovirus causing diverse clinical manifestations ranging from asymptomatic or mild to more severe outcomes, dependent on the haematological and/or immunological status of the host.
Theoretically, we can explain the more severe outcomes of older workers after displacement from relatively high labour costs, which result from delayed compensation schemes, higher wages due to the strong bargaining position of well-protected older workers or costly special provisions for older workers in collective bargaining schemes.
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