By contrast, drought was applied in a more severe and transient manner, leading to profound changes in transcript levels in all tissues analyzed.
I see this project as continuing that train of thought in a more severe and direct, yet abstract manner.
Our findings bear out our hypothesis that the mixed strain mouse model develops, in a time-related manner, progressively more severe lesions in the brachiocephalic artery and that chronic stress increases many of the vulnerable plaque-like components found within these lesions.
Myotonic dystrophy (DM; also known as dystrophia myotonica), the most common form of muscular dystrophy in adults, is a progressively disabling disease that is inherited in an autosomal dominant manner, with anticipation (more severe phenotype and earlier onset from one generation to the next) and variable expressivity (symptoms vary among individuals) (Harper, 2001).
At the end of the experiments, these disrupted biochemical markers corresponded to pathologies evidenced in a blinded manner: notably hepatorenal deficiencies, more severe in males, and female mammary tumors, which led to premature deaths.
Furthermore, when these members are lost suddenly, their forces are shed in a dynamic manner into the structure, causing more severe damage.
Using the McDonald TT" chamber, we locally silenced Ndel1 by siRNA in transected axons; we observed decreased regeneration in vivo (Fig. 6) in a manner reminiscent of, but to a more severe extent than sensory axons lacking Vimentin [27].
We found that maytansinol reduced the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53−/− cells at both low and high doses (Fig. 3).
Thus, these Hyp-GALT genes function in a largely redundant manner, and it is anticipated that more severe biochemical and physiological phenotypes will occur when multiple genetic mutants are studied, revealing additional AGP functions.
To assess whether a more severe hypoxic exposure would affect exosome release in a similar manner, cells were cultured at 0.1% O2 for 24 hours, prior to ExoquickTM precipitation and NTA.
