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Even in our study, although clinical symptoms are different, patients showing more severe features had a severely inactivating mutation (9).
Because influenza may present with more severe features relative to ARI of other etiologies, we hypothesized that symptom severity would be rated higher among adults with RT-PCR confirmed influenza.
While these clinical features are consistent with common HPE microforms, especially those linked to defective signaling by Sonic Hedgehog, we have insufficient evidence so far that functionally abnormal DISP1 alleles will commonly contribute to the more severe features of typical HPE.
Compared to 50 age-matched controls of idiopathic FSGS with typical perihilar scars, the group of idiopathic collapsing FSGS displayed black racial predominance, a higher serum creatinine and more severe features of nephrotic syndrome at biopsy.
In moribund mice, WT infection (Figure 7A, D) showed more severe features of meningeal thickening compared to ΔinhA infection (Figure 7E, F).
Other more severe features of ibuprofen toxicity should be managed appropriately.
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The clinical features of the six males are summarized in Table 1 and illustrated in Figure 1B G, in which their more severe dysmorphic features are evident when compared with affected male offspring of females with CFNS, who are obligate carriers of the EFNB1 mutation (Fig. 1A).
Changes of neurosteroids concentrations in CH patients were significant only for AP, which may contribute to the more severe clinical features of CH vs CM and EM.
These potential biases are taken into account by a recent large study of patients with BD (n = 587), thereby confirming childhood trauma as being associated with more severe clinical features in BD, including an earlier age of onset, an increased risk of at least one lifetime suicide attempt, rapid cycling, an increased number of mood episodes and substance misuse (Etain et al. 2013a).
Higher scores represent more severe autistic features.
Other mutations cause different phenotypes and in general are associated with more severe progeroid features similar or identical to HGPS.
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more severe droughts
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