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In more severe exacerbations, GPs preferred a course of seven, ten, or fourteen days.
Thirty-seven per cent of patients had two or more moderate exacerbations and 2% had two or more severe exacerbations.
In an accompanying editorial, Babu and Chauhan [ 2] advocated the 'timely use of non-invasive ventilation in more severe exacerbations'.
Respiratory viruses produce longer and more severe exacerbations and have a major impact on healthcare utilization [ 8, 84].
The children who were reported to have had more than one allergic co-morbidity were especially at risk of having less well controlled asthma and more severe exacerbations.
This cohort included COPD patients with a postbronchodilatador FEV1 below 50% from the reference who reported three or more severe exacerbations in the previous year.
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In a more severe exacerbation duration of seven to fourteen days was more common.
In addition, having one or more severe exacerbation in the last year or poor pulmonary function (defined as forced expiratory volume in 1 second less than 60%% of predicted) are recognized as modifiable risk factors for poor outcomes.
Colonization with NTHi is associated with more severe COPD exacerbations [62].
Patients with severe airflow obstruction experienced more severe respiratory exacerbations, especially if they presented with ILI of more than forty-eight hours duration.
As the disease worsens, e.g. Gold 2+, patients also experience progressively more frequent and severe exacerbations, which are due in greatest part to bacterial and viral chest infections, as well as pollutants [ 6– 8].
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