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More than 400 of these were "at the more severe end of the scale".
Non-alcoholic steatohepatitis (NASH) represents the more severe end of hepatic steatosis and is associated with progressive liver disease.
At the more severe end are those who are recklessly jumping down flights and running into oncoming traffic.
"At the more severe end of the scale, for those with severe osteoarthritis, we asked if they had been given the opportunity to see a specialist to talk about joint replacement.
Dr. Volkmar said that although the proposed diagnosis would be for disorders on a spectrum and implies a broader net, it focuses tightly on "classically autistic" children on the more severe end of the scale.
"The reduction of 4.6% is on the more severe end of what we have been planning for and it will require the council to take some difficult decisions.
Similar(7)
The accumulation of 465 mM glucose and 47 mM cellobiose as hydrolysis products caused more severe end-product inhibition of cellulosomes and β-glucosidases.
Hydrolysis of lignocellulose at elevated substrate concentrations leads to substantially increased absolute sugar concentrations, and the accumulation of hydrolysis products along with diffusion limitations causes more severe end-product inhibition of cellulases during hydrolysis.
It should be noted that loss or blunting of the nocturnal dip is associated with more severe end-organ damage and increased risk of cardiovascular events, and 'non-dipper' hypertensive individuals frequently belong to high- or very high-risk categories (de la Sierra et al., 2010).
It merges at the more serious end into severe assaults, rape and even murder2.
Although hospital-based data suffer several limitations, including a bias to more severe disease, the severe end of the disease spectrum is where the biggest health impact will be made by both vaccines and therapeutics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com