Sentence examples for more severe differentiation from inspiring English sources

In the absence of LIF, ER stress inducers thapsigargin, tunicamycin and ionomycin lead to more severe differentiation and higher expression of ER stress-related genes and VEGFA, while tauroursodeoxycholic acid, salubrinal and BHA, the ER stress inhibitors, blocked the expression of ER stress-related genes and VEGFA caused by the removal of LIF, and thus prevented cell differentiation.

The bacterial community between plots of the same N or P input rate was much more dissimilar with the higher input level, indicating more severe niche differentiation in pots with higher N or P input.

c587-mediated wnt2 and wnt4 double knockdown results in more severe germ cell differentiation defects than wnt2 or wnt4 single knockdown.

Do doubly deficient Roquin1/Roquin2 mice have a more severe defect in Tfh differentiation, or does it extend beyond Tfh cells?

Regarding the question of whether doubly deficient Roquin1/Roquin2 mice have a more severe defect in Tfh differentiation, we showed in Pratama et al. Immunity (2013) that the Tfh defect observed in Roquin1 ringless mice is not seen in Roquin2 ringless and that double ROQUIN1/2 RING deficiency in fact corrects the Roquin1 ringless Tfh defect.

Interestingly, in developing airways defects in Clara cells differentiation were similar between Pofut1/Shh-Cre and Rbpj/Shh-Cre mutants [37]; however, defects in neuroendocrine cells differentiation were more severe in Pofut1 deletion than in Rbpj deletion and it was ascribed to a marginal reduction of Hes1 expression by Rbpj deletion [38].

Overall, primary macrophages had a more severe inhibitory effect on osteoblast differentiation than the macrophage cell line, with greater apoptosis and collagen I reduction.

These data demonstrate Fgfr3 dose-dependent abnormalities of organ of Corti differentiation that are more severe at apical (low frequency) than basal (high frequency) regions, consistent with the hearing loss in Muenke model mice.

Although the phenotype of miR-143/145 deficient mice resembles the loss of Dicer, the phenotypes of SM-Dicer KO mice were far more severe suggesting that additional miRNAs are involved in maintaining postnatal SMC differentiation.

Since Akt1-/; Akt2+/- mice displayed a more severe lactation defect than Akt1-/; Akt2+/+ mice, we examined alveolar development and differentiation in these mice.

However, it is notable that disruption of the Map3k1 PHD motif has a more dramatic effect upon B-cell development than kinase domain ablation, the degree of embryonic lethality encountered is more severe in Map3k1 mPHD than Map3k1 ΔKD mice and there are more severe mesoderm and neuroectoderm differentiation defects in Map3k1 mPHD than Map3k1 ΔKD stem cells.