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The location of these residues at the juncture of these two protein regions would rationalize the more severe destabilization observed when these residues are substituted to generate R63S (Tm ∼43 °C) and W11F (Tm ∼25 °C), with melting temperatures reflecting destabilization of both MftR regions D1 and D2.
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Upon further aging of these mice, or in the homozygous mouse where the disease is more severe, it is likely that microtubule destabilization results.
A total or partial meniscectomy produces a great destabilization of the joint, thus leading to a rapid degeneration and a more severe pathology (McDermott & Amis 2006).
The more severe crashes.
Sentences are more severe.
More severe or less severe?
Corruption is more severe.
Their words became more severe.
The negativity is more severe".
And punishments are more severe.
Still, his episodes grew more severe.
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