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More plaques usually meant more severe dementia, in both older and younger patients.
7, 8 In contrast, NH care typically serves persons with more severe dementia.
Most participants had mild dementia, but one trial was conducted with nursing home residents who had more severe dementia.
There was a significant second-order time trend in P-ADL functioning, and more severe dementia at baseline was associated with declined P-ADL functioning over time.
The worsening was associated with more severe dementia, higher physical comorbidity, agitation, apathy and no use of anxiolytics and antidementia medication.
Sampson et al. [ 56] show that transitions to hospital at this stage are detrimental for both the person and the carer, particularly for people with more severe dementia.
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Nevertheless, future studies should examine whether EL may still be applicable in older adults with more severe dementias residing in nursing homes, given that some studies have reported positive effects in this population using selected tasks that were adjusted to the participants' performance levels.
Some challenges, such as unmeasured confounding or missing data, are common in many research areas; others, such as outcome measurement error and lack of a "gold standard" outcome assessment, are more pervasive or more severe in dementia research [ 1– 3].
Recent studies described reduced numbers of Tregs in patients with Alzheimer's disease, and the more severe the dementia, the greater the decline of Treg numbers (Larbi et al, 2009; Saresella et al, 2010).
If mortality rates decline among those with diabetes without reducing disease severity, and if more severe diabetes influences dementia risk, dementia/CIND rates among people with diabetes could potentially increase.
In conclusion, agitation was less severe in 2010/2011 than in 2004/2005 among nursing home residents with a milder degree of dementia, and more severe in residents with severe dementia.
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