Additionally, based on general knowledge of risk factors for progressive joint damage in RA (longer symptom duration, presence of RA-related auto-antibodies, higher numbers of swollen joints and elevated acute-phase reactants are all associated with more severe damage), we made several other hypotheses.
While minimal cell damage can be repaired by removal of damaged organelles via cellular stress response pathways or autophagy, more severe damage is associated with structural changes (e.g., swelling of the cell membrane).
"What we did not estimate accurately was the duration of strong winds, which resulted in significantly more severe damage".
Such action would be taken to prevent more severe damage to electrical circuits and to allow power to be restored more quickly once the storm had passed.
Formula One cars are designed to rigorous safety specifications but are built with the expectation of impacts with trackside structures such as tyre barriers or safety walls, rather than recovery vehicles, which would have caused far more severe damage.
To avoid more severe damage to our cultural heritage, wildlife and countryside in the future, we need to move towards a better, more sustainable approach to energy use, based on energy conservation, localisation and greater use of renewable sources.
Mr. Bloomberg said electricity could be turned off in some parts of Lower Manhattan and in other low-lying areas to avoid more severe damage from flooding, but he added that no decision had yet been made.
A shutdown in Manhattan, where the company's cables and pipes mostly run beneath the streets, would prevent more severe damage to electrical circuits and allow power to be restored more quickly once the storm passes.
If unchecked, nonproliferative diabetic retinopathy can lead to worsened blood flow to the retina, more severe damage, and the appearance of new abnormal blood vessels on the optic disk, retina, and even iris (proliferative diabetic retinopathy).
After Mr. Sokol took over Netjets in July 2009, some critics complained about his management style and his strategy for shrinking the company, which had been ailing even before the financial crisis did more severe damage.
Mr. Bloomberg also said that Consolidated Edison could pre-emptively turn off electricity in some parts of downtown Manhattan and in other low-lying areas of the city to avoid more severe damage from flooding, but he added that no decision had been made.
