Several of these cases represented undiagnosed or insufficiently treated patients with more severe course that necessitated hospitalisation for identification of the causative agent and further treatment.
In immunosuppressed patients infection with mixed HCMV populations was associated with a more severe course of infection.
A higher incidence of IUGR in this group suggests a more severe course of the experienced pregnancy complications.
Some evidence suggests that individuals with bipolar spectrum disorders (BSD) generate stressful life events, contributing to a more severe course of disorder.
Impulsivity is substantially higher in bipolar patients (BP) and may be associated with a more severe course of illness, but no studies have so far examined the relationship between impulsivity and functional outcome in BP.
To investigate a previously reported observation that the presence of diffuse, as compared with localized, fundus flecks is an indicator of a more severe course for visual acuity (VA) loss beyond 20/200 in patients with Stargardt's disease.
Further we assumed that 20% of all inpatient CAP cases took a more severe course.
Alternatively, those who are more impulsive may have a more severe course of illness.
This gives some support to impulsivity as a trait which may lead to a more severe course of illness.
Furthermore, impulsivity in bipolar disorder (BD) has been linked to poorer outcome, including a more severe course and suicidality (Watkins and Meyer 2013; Swann et al. 2009a).
Additionally, self-reported impulsivity seems to be higher among bipolar patients, both parameters being possibly associated with a more severe course of illness.
